A Novel Blood-Based Epigenetic Clock for Intrinsic Capacity Predicts Mortality and is Associated with Clinical, Immunological and Lifestyle Factors
It is now a consensus in the scientific community that Systemic Chronic Inflammation (SCI), arising as an immune response to environmental and social insults, is the root cause of many diseases.
Comprehensive pan‑cancer analysis of infammatory age‑clock‑related genes as prognostic and immunity markers based on multi‑omics data.
It is now a consensus in the scientific community that Systemic Chronic Inflammation (SCI), arising as an immune response to environmental and social insults, is the root cause of many diseases.
Inflammatory aging clock: A cancer clock to characterize the patients’ subtypes and predict the overall survival in glioblastoma
It is now a consensus in the scientific community that Systemic Chronic Inflammation (SCI), arising as an immune response to environmental and social insults, is the root cause of many diseases.
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
We developed a deep-learning method based on patterns of systemic age-related inflammation. The resulting inflammatory clock of aging (iAge) tracked with multimorbidity, immunosenescence, frailty and cardiovascular aging, and is also associated with exceptional longevity in centenarians.
White Paper: Novel Biomarkers of Chronic Inflammation/ Immune Health
It is now a consensus in the scientific community that Systemic Chronic Inflammation (SCI), arising as an immune response to environmental and social insults, is the root cause of many diseases.
White Paper: The critical role of understanding chronic inflammation
The importance of novel inflammatory biomarkers immune profiling in prediction of coronavirus disease severity.
Chronic inflammation in the etiology of disease across the life span
In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress.
Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy
Despite clear differences in immune system responses and in the prevalence of autoimmune diseases between males and females, there is little understanding of the processes involved.
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
Low-grade chronic inflammation has been associated with many of the diseases associated with aging, but the mechanisms that produce this inflammation are poorly understood.
Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans
A longitudinal study reveals in older adults systemically reduced immune cell signaling responses that are stable at least 3 years and are predictive of cardiovascular disease.
Cytomegalovirus infection enhances the immune response to influenza
Cytomegalovirus (CMV) is a b-herpesvirus present in a latent form in most people worldwide. In immunosuppressed individuals, CMV can reactivate and cause serious clinical complications, but the effect of the latent state on healthy people remains elusive.
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination
There are marked differences between the sexes in their immune response to infections and vaccination, with females often having significantly higher responses.
Understanding Inflammation
Inflammation has been found to be an underlying cause in many diseases, making it a hot topic in the health media. But what do we really know about chronic inflammation and its effects on the body?
Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians
Inflammation has been found to be an underlying cause in many diseases, making it a hot topic in the health media. But what do we really know about chronic inflammation and its effects on the body?
Systemic Inflammation Predicts All-Cause Mortality: A Glasgow Inflammation Outcome Study
Markers of the systemic inflammatory response, including C-reactive protein and albumin, as well as neutrophil, lymphocyte and platelet counts have been shown to be prognostic of survival in patients with cancer. The aim of the present study was to examine the prognostic relationship between these markers of the systemic inflammatory response and all-cause, cancer, cardiovascular and cerebrovascular mortality in a large incidentally sampled cohort.
Homeostasis, Inflammation, and Disease Susceptibility
While modernization has dramatically increased lifespan, it has also witnessed the increasing prevalence of diseases such as obesity, hypertension, and type 2 diabetes. Such chronic, acquired diseases result when normal physiologic control goes awry and may thus be viewed as failures of homeostasis.
The role of inflammation in age‐related disease
It is now recognized that a mild pro‐inflammatory state is correlated with the major degenerative diseases of the elderly.
Inflammation as “common soil” of the multifactorial diseases
Inflammation is classically recognized as an essential step for the control of microbial invasion or tissue injury as well as for the maintenance of tissue homeostasis under a variety of noxious conditions.
