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This study presents a novel epigenetic clock for intrinsic capacity (IC) based on DNA methylation, trained on clinical assessments across five health domains in a cohort of 1,014 individuals aged 20–102. The DNAm IC clock predicts mortality, correlates with immune resilience and functional health, and provides a molecular link between aging biology, immunosenescence, and lifestyle factors such as diet and physical activity. Elevated DNAm IC levels correlated with low Inflammatory Age