Research on inflammatory aging, immune health and the biology of aging, alongside Edifice's white papers.
19 publications
Nature Medicine · Consensus perspective
An expert consensus co-authored by Jamie Justice, Executive Director of XPRIZE Healthspan, and Edifice founder David Furman sets five criteria for immune aging biomarkers in clinical trials and names iAge® (or similar inflammaging scores) as a prespecified biomarker for the XPRIZE Healthspan competition.
Nature Aging · Research paper
A DNA methylation clock estimates intrinsic capacity and links functional health with mortality, immune and inflammatory markers, and lifestyle factors.
Scientific Reports · Research paper
An analysis across 33 cancer types examines inflammatory age-related genes, highlighting DCBLD2 and a five-gene prognostic signature for uveal melanoma.
Frontiers in Genetics · Research paper
Researchers use inflammation-related gene expression to group glioblastoma patients by inflammatory age and examine associations with survival, immune activity and stem-cell characteristics.
Nature Aging · Research paper
Developed from 1,001 participants, iAge tracks age-related inflammatory patterns associated with multimorbidity, immune aging, frailty and cardiovascular aging, with CXCL9 as a key contributor.
Edifice Health · White paper
A white paper on chronic inflammation biomarkers, immune health, and potential applications in aging, disease and nutrition.
Edifice Health · White paper
A white paper exploring chronic inflammation, immune resilience, and the potential role of inflammatory biomarkers in understanding coronavirus disease severity.
Nature Medicine · Research paper
A perspective on the mechanisms and risk factors behind systemic chronic inflammation, including environmental exposures, inactivity, diet and stress, and possible prevention and treatment strategies.
The Journal of Immunology · Research paper
A multicenter study identifies immature-neutrophil signatures that differ by sex and increase during pregnancy, providing insight into variation in innate immune responses.
Nature Medicine · Research paper
Inflammasome gene activity distinguishes older adults with different inflammatory and cardiovascular profiles, linking nucleotide metabolites, IL-1β, hypertension and arterial stiffness.
Cell Systems · Research paper
A longitudinal study links reduced immune-cell responsiveness in the JAK-STAT pathway with chronic inflammation and cardiovascular risk in older adults.
Science Translational Medicine · Research paper
A systems study finds enhanced influenza vaccine responses in young CMV-positive adults, while examining how age and latent infection shape immune function.
PNAS · Research paper
A systems analysis links testosterone-associated lipid-metabolism gene signatures with sex differences in antibody responses to influenza vaccination.
Johns Hopkins Health Review · Article
An overview of chronic inflammation, its links to disease, and the evidence and open questions around lifestyle choices and inflammation.
EBioMedicine · Research paper
A longitudinal study of very old adults and centenarians finds that inflammation predicts survival, physical capability and cognition, while telomere length does not predict successful aging.
PLOS ONE · Research paper
A large cohort study examines how common inflammatory blood markers, individually and in combination, relate to all-cause, cancer, cardiovascular and cerebrovascular mortality.
Cell · Research paper
A review explores how physiological control systems maintain stability and how their disruption connects chronic inflammation with susceptibility to disease.
Aging · Research paper
An NIH geroscience workshop report examines the origins and consequences of chronic low-grade inflammation and research priorities for improving healthspan.
Autoimmunity Reviews · Research paper
A review examines inflammatory mediators shared across rheumatic and other complex diseases, including metabolic, cardiovascular and neurodegenerative conditions.
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Featured research includes work by Edifice founders and scientific advisors; authorship varies by paper. Wider literature is included for context and is not presented as validation of the iAge® test.
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