The importance of novel inflammatory biomarkers immune profiling in prediction of coronavirus disease severity.
In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress.
Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy
Despite clear differences in immune system responses and in the prevalence of autoimmune diseases between males and females, there is little understanding of the processes involved.
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
Low-grade chronic inflammation has been associated with many of the diseases associated with aging, but the mechanisms that produce this inflammation are poorly understood.
Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans
A longitudinal study reveals in older adults systemically reduced immune cell signaling responses that are stable at least 3 years and are predictive of cardiovascular disease.
Cytomegalovirus (CMV) is a b-herpesvirus present in a latent form in most people worldwide. In immunosuppressed individuals, CMV can reactivate and cause serious clinical complications, but the effect of the latent state on healthy people remains elusive.
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination
There are marked differences between the sexes in their immune response to infections and vaccination, with females often having significantly higher responses.